Lipopeptide Topical Peptide

Lipopeptide 200mg (Topical)

This product is intended for research purposes only. To be used by trained professionals only.

Lipopeptides are molecules built from a fatty acid chain linked to amino acid residues. This design gives them both water-loving and fat-loving qualities. That means they can interact well with cell membranes in both bacteria and human skin cells.

These compounds are produced by microorganisms, especially strains of Bacillus subtilis and Bacillus sp, during fermentation. The presence of lipopeptides in these organisms has made them popular for research focused on antimicrobial, anti-inflammatory, and skincare applications. Different structures and surfactin isoforms result in a wide range of biological activity, including actions against fungi and bacteria.

In skin research, topical lipopeptides are tested for how they affect hydration, elasticity, and redness. Because of their structure, they can reach deeper layers of the skin, crossing membranes made of lipids. Some research models also explore how these peptides influence pores, helping improve barrier function.

The activity of these peptides depends on both the length of their fatty acid chains and the specific peptide sequence. These variations are being studied to understand their roles in skin firmness, irritation control, and microbial inhibition.

Potential Benefits of Lipopeptide Topical Peptide

Lipopeptides have strong antimicrobial and antibacterial activity. In lab tests, they have been shown to disrupt the membranes of harmful microorganisms, including Pseudomonas aeruginosa and Pseudomonas fluorescens.

Their fatty acid chains insert into bacterial cell membranes, damaging ion channels and causing leakage, which leads to cell death. This action is similar to antibiotics like polymyxin B and daptomycin, though the mechanism is not identical.

One of the most studied lipopeptides, surfactin, is known for its ability to reduce inflammation. In skin models, it has shown to decrease IL-6 levels, a key marker in skin irritation. This anti-inflammatory activity helps create a healthier skin environment and supports skin barrier recovery. Because of this, surfactin and related antimicrobial peptides are under great interest in the field of skincare science.

Fengycin, another lipo peptide from strains of Bacillus, is being researched for its antifungal activity. It targets fungal infections in a way that appears to preserve skin cells while attacking the invading organisms. These actions make lipopeptides useful antimicrobial agents for research related to topical formulations.

In skincare research, lipo peptides are also studied for their role in supporting collagen and fibrillin-1 production. These proteins help maintain elasticity and reduce the appearance of wrinkles. Studies using reconstituted cell lines have shown improved cohesion and strength in the outer skin layer when treated with certain lipopeptides.

The activity of lipopeptides in these models has made them appealing candidates for research exploring skin rejuvenation strategies.

Their resistance to degradation in plasma and serum enhances their appeal for extended lab testing. Researchers find them useful in studies that simulate skin damage and recovery. Because lipopeptides don’t break down easily, they can be monitored over time in vitro. These properties make lipopeptide biosurfactants valuable in skin-focused laboratory studies.

Their solubility in mm sodium phosphate and ability to mix with surfactants and active compounds like formic acid make them ideal for lab formulations. These solutions are often tested on skin cell models to track outcomes like reduced inflammation or increased hydration.

Some labs use mass spectrometers to analyze the synthesis and extraction of lipopeptides. This helps detect variations in their lipid chains, which affect solubility, penetration, and efficacy. The number of carbon atoms in the fatty acid chain is often tied to their potency.

Importantly, lipo peptides can also affect part of the metabolism in bacterial cells, making them useful in broader antimicrobial studies. They act as both antimicrobials and anti-inflammatory agents, with promising potential in cosmetic science.

How Should Lipopeptide Be Stored?

To keep lipo peptides stable, store them at -20°C in airtight, sterile containers. If reconstituted, short-term storage at 4°C is acceptable. Avoid repeated freeze-thaw cycles, which can harm their structure and lower biological activity.

Once dissolved, it’s best to aliquot them into smaller portions. This helps avoid degradation from air or moisture. Solutions should be clear and free of contamination. They are often stored in phosphate-buffered systems or combined with surfactants to maintain stability.

Some formulations include formic acid to increase solubility. Depending on the peptide’s fatty acid chain, the solution may vary in clarity and pH, which also affects its shelf life.

Store peptides in a dark environment and clearly label all containers. Lipopeptides are strong, but like all experimental agents, they need proper care. Use protective gear, sterile tools, and follow lab safety rules. This ensures results remain reliable in both antimicrobial and skincare model studies.

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References:

[1] Pilz M, Cavelius P, Qoura F, Awad D, Brück T. Lipopeptides development in cosmetics and pharmaceutical applications: A comprehensive review. Biotechnol Adv. 2023 Oct;67:108210.

[2] Kanlayavattanakul M, Lourith N. Lipopeptides in cosmetics. Int J Cosmet Sci. 2010 Feb;32(1):1-8.

[3] Wiman E, Zattarin E, Aili D, Bengtsson T, Selegård R, Khalaf H. Development of novel broad-spectrum antimicrobial lipopeptides derived from plantaricin NC8 β. Sci Rep. 2023 Mar 13;13(1):4104.

[4] Hamley IW. Lipopeptides: from self-assembly to bioactivity. Chem Commun (Camb). 2015 May 21;51(41):8574-83.

[5] Hamley IW, Kirkham S, Dehsorkhi A, Castelletto V, Reza M, Ruokolainen J. Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures. Chem Commun (Camb). 2014 Dec 28;50(100):15948-51.

[6] Coutte F, Lecouturier D, Dimitrov K, Guez JS, Delvigne F, Dhulster P, Jacques P. Microbial lipopeptide production and purification bioprocesses, current progress and future challenges. Biotechnol J. 2017 Jul;12(7).

Molecular formula: C38H68N6O8

Molecular weight: 736.9 g/mol

Sequence: Pal-Gly-Gln-Pro-Arg

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our America Direct Peptides website: https://america.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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