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Epithalon, also known as Epithalamin or Epitalon, is a peptide recognized for its anti-aging effects. It can significantly slow down the aging process and acts as an effective antioxidant, comparable to melatonin. This synthetic peptide is made from four amino acids: glycine, glutamic acid, alanine, and aspartic acid. It is based on a natural peptide called epithalamion found in the human pineal gland and has been shown to boost telomerase production.
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What Is Epithalon?
Epithalon, also known as epitalon or epithalamin, is a bioactive compound synthesised to mimic the peptide naturally occurring in the human pineal gland. The ynthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly functions primarily as a telomerase activator, and plays a role in maintaining telomere length, which is associated with cellular ageing and lifespan regulation.
It is thought to exert its effects by regulating the cell cycle through telomerase activation, an enzyme that extends the DNA’s protective telomeres. By enhancing telomerase activity, Epithalon may support genomic stability and cellular integrity, offering a mechanism through which it could contribute to anti-aging processes.
Beyond its implications for ageing, Epithalon is also under investigation for its role in modulating circadian rhythms, endocrine function, and immune response, utilising its capacity to influence a variety of physiological systems.
The Mechanism Of Action of Epithalon Peptide
Epithalon operates through a multifaceted mechanism that primarily involves the activation of telomerase, a ribonucleoprotein enzyme fundamental in maintaining telomere integrity within eukaryotic cells. By binding to specific telomeric regions, it facilitates the addition of TTAGGG nucleotide repeats to the ends of chromosomes, effectively counteracting the natural shortening that occurs with each cell division. This preservation and elongation of telomeres serve to delay cellular senescence, thereby promoting the longevity and sustained replication capacity of somatic cells.
Beyond its role in genomic stability, Epithalon is believed to modulate the expression of genes engaged in cellular stress responses, potentially influencing pathways related to apoptosis and autophagy. Additionally, by interacting with the pineal gland, Epithalon may enhance the secretion of melatonin, a hormone pivotal to regulating circadian rhythms and possessing antioxidative properties. This hormonal modulation can lead to improved synchronization of bodily processes with environmental cycles, thereby optimizing physiological functions and potentially curbing the onset of age-related disorders.
Moreover, Epithalon’s influence extends to the immune system, where it is thought to enhance immune surveillance and response. This is achieved by modulating the production and activity of cytokines, which are critical in orchestrating immune responses. Collectively, these diverse mechanisms of action reinforce Epithalon’s potential as a therapeutic agent with broad-spectrum benefits in the context of aging and associated physiological decline.
Structure of Epithalon
Sequence: H-Ala-Glu-Asp-Gly-OH
Molecular Formula: C14H22N4O9
Molecular Weight: 390.349
PubChem CID: 219042
What Are The Research Benefits of Epithalon
Peptide Bioregulator: Epithalon is a synthetic peptide consisting of four amino acids – alanine, aspartic acid, glutamic acid, and glycine. It acts as a mimic to Epitalon, a natural peptide secreted by the pineal gland [1].
Telomere Elongation: The peptide has been reported to support telomere elongation by activating telomerase in human somatic cells, which helps maintain chromosomal stability, contributing to anti-aging effects and delays cellular ageing processes [2].
Potential Anti-Aging Benefits: Epithalon has been associated with potential anti-aging benefits, including improving skin health and addressing some aspects of physical aging [3].
Reduction of Chromosomal Aberrations: Treatment with Epithalon has been associated with a decrease in chromosome aberrations, suggesting a possible role in genetic stability and cellular health [4].
Regulation of Melatonin Production: The major mechanism of Epithalon is believed to involve the regulation of melatonin production in the pineal gland, potentially contributing to sleep regulation and circadian rhythm balance [5].
Healing and Tissue Repair: Epithalon has been mentioned among peptides that aid in healing and tissue repair, suggesting potential benefits in wound healing, recovery from injury, or management of degenerative conditions [6].
Immunological Impact Studies: By modulating cytokine activity, Epithalon can be a focal point for research into immune system enhancement and resistance to infections, providing insights into immune modulation in aging populations.
Cellular Stress Response Research: Exploring how Epithalon affects gene expression related to apoptosis and autophagy could reveal novel pathways for promoting cellular repair and resilience under stress conditions.
Potential Anti-Cancer Applications: Due to its role in telomere maintenance, Epithalon may hold potential as an adjunctive compound in oncology research, aimed at understanding its impact on tumor progression and treatment resistance.
Neuroscience and Cognitive Health: Researching Epithalon’s effects on the pineal gland and neuroendocrine factors can enhance understanding of cognitive aging and neuroprotection, with implications for neurodegenerative disease studies.
Buy Epithalon Peptide Vial for research online today! Available in 10mg and 100mg vials.
Buy Epithalon Thymalin Peptide Stack
Buy Epithalon Thymalin Peptide Stack for research and save 10%. The stack combines two powerful peptides known for their anti-aging and immune-boosting effects.
Epithalon is a synthetic peptide that enhances telomerase activity, promoting telomere maintenance and cellular longevity.
Thymalin, derived from the thymus gland, stimulates the immune system and may support tissue regeneration. Discover more about Thymalin here.
This combination is believed to enhance the benefits of each peptide, providing cellular rejuvenation through telomere support and improved immune function. Such stacks are primarily studied for potential interventions in age-related decline and immune dysfunction.
Buy Epithalon Nasal Spray
Buy Epithalon nasal spray, available in 15ml and 30ml glass spray bottles. This easy-to-use formulation is designed for simple administration and quick absorption.
Unlike injectable forms, the nasal spray facilitates the peptide’s delivery through the nasal mucosa, which may allow for quicker systemic distribution. This method of administration is particularly advantageous for individuals seeking non-invasive options.
The Epithalon nasal spray may help with telomere maintenance and anti-aging, supporting research into optimizing drug delivery for better peptide efficacy. America Researchers often explore this method to assess its effectiveness in preclinical and clinical settings, focusing on its impact on cellular longevity and overall health.
Frequently Asked Questions (FAQs) about Epithalon Peptide
What primary research areas are being explored with Epithalon?
Epithalon research primarily focuses on anti-aging and longevity studies, cellular stress response mechanisms, telomerase activation, and potential treatments for age-related diseases. Researchers are also investigating its effects on the immune system, cancer biology, and circadian rhythm regulation.
How does Epithalon contribute to an understanding of telomerase?
Epithalon is known to activate telomerase, which helps maintain telomere length in cells. By studying its interaction with telomerase, researchers gain insights into the underlying molecular pathways that could lead to breakthroughs in aging research and chromosome stability.
What methodological approaches are used in Epithalon research?
Researchers employ a variety of methodologies including in vitro studies, animal models, and clinical trials to examine Epithalon’s biochemical interactions and physiological effects. Techniques such as gene expression analysis, telomere length measurement, and immune response assays are commonly used.
Where is the best place to buy Epithalon?
It is important to buy Epithalon from reputable sources such as Direct Peptides America to ensure the quality and purity of the product. We also offer worldwide shipping with tracking for added convenience and security. However, it is crucial to check the legality of Epithalon in your country before making a purchase.
Is Epithalon legal?
The legality of Epithalon varies depending on the country and its regulatory framework. In certain regions, it may be classified as a research compound or supplement, subject to specific restrictions regarding its sale and use. It is essential to consult local regulations and legal guidelines when considering the acquisition or use of Epithalon.
In the United States, Epithalon is not approved by the FDA for medical use and is typically available only for research purposes. Individuals should seek advice from legal and healthcare professionals to ensure compliance with applicable laws and regulations when choosing to buy Epithalon.
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Summary of Research Applications
- Telomere maintenance
- Cellular longevity
- Genomic stability
- Circadian rhythm regulation
- Immune system enhancement
- Anti-aging potential
- Stress response modulation
- Potential adjunctive in cancer research
- Potenial cognitive and neuroprotective benefits
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Epithalon Peptide Quality Assured
At Direct Peptides, we prioritize the highest standards of quality and purity in our Epithalon peptides. Our commitment to excellence starts with selecting superior-grade raw materials and continues with rigorous quality control tests.
Each batch is produced in state-of-the-art facilities and meets strict regulatory and industry standards. We conduct thorough analyses, including HPLC and mass spectrometry, to carefully verify purity, potency, and safety.
Researchers can trust Direct Peptides to provide high-quality Epithalon, ensuring reliable results in their studies. This strong focus on quality assurance gives researchers confidence in their experimental outcomes.
View the HPLC Certificate here.
References For Further Reading
[1] V N Anisimov and V K Khavinson (2010) Peptide bioregulation of aging: results and prospects – Biogerontology, 2010 Apr, Volume 11 (Issue 2), Pages 139-49.
[2] V K Khavinson, I E Bondarev, and A A Butyugov (2003) Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells – Bulletin of Experimental Biology and Medicine, 2003 Jun, Volume 135 (Issue 6), Pages 590-2.
[3] N I Chalisova, N S Lin’kova, A N Zhekalov, A O Orlova, G A Ryzhak, and V Kh Khavinson (2014) Short peptides stimulate skin cell regeneration during ageing – Advances in Gerontology, 2014, Volume 27 (Issue 4), Pages 699-703.
[4] V Kh Khavinson, A Iu Solov’ev, D V Zhilinskiĭ, L K Shataeva, and B F Vaniushin (2012) Epigenetic aspects of peptide regulation of aging – Advances in Gerontology, 2012, Volume 25 (Issue 1), Pages 11-22.
[5] O V Korkushko 1, V Kh Khavinson, V B Shatilo, and L V Magdich (2004) Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people – Bulletin of Experimental Biology and Medicine, 2004 Apr, Volume 137 (Issue 4), Pages 389-91.
[6] V Kh Khavinson 1, I E Bondarev, and A A Butyugov (2003) Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells – Bulletin of Experimental Biology and Medicine, 2003 Jun, Volume 135 (Issue 6), Pages 590-2.
[7] I A Vinogradova 1, A V Bukalev, M A Zabezhinski, A V Semenchenko, V Kh Khavinson, and V N Anisimov (2007) Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes – Bulletin of Experimental Biology and Medicine, 2007 Dec, Volume 144 (Issue 6), Pages 825-30.
[8] G Kossoy, V N Anisimov, H Ben-Hur, N Kossoy, and I Zusman (2006) Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice – In Vivo, 2006 Mar-Apr, Volume 20 (Issue 2), Pages 253-7.
Why Choose Direct Peptides America?
Buy Epithalon today from Direct Peptides America, your trusted provider for Epithalon peptides. What sets us apart is our wide range of formulations, including peptide vials in 10mg and 100mg options, peptide stacks for potential synergistic effects, nasal sprays in 15ml and 30ml sizes, and ready-to-use pre-mixed peptide pens. We cater to various research needs, ensuring that researchers get the exact formulation they need for their studies.
Explore our peptide supply range for peptide reconstitution, which includes bacteriostatic water, syringes, alcohol swabs, pen needle tips, and empty cartridges. These tools are integral for ensuring precise and safe peptide preparation, supporting researchers in their various experimental needs.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our America Direct Peptides website: https://america.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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Exploring Anti-Aging: The Epithalon and Thymalin Stack
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Epithalon For Anti-Aging
This blog explores the synthetic peptide Epithalon, researched by Professor Vladimir Khavinson, as a potential anti-aging breakthrough. It discusses its ability to stimulate telomerase production, maintain telomere length, and possibly extend lifespan, while also highlighting benefits like better sleep, immune support, and improved skin health.
