AICAR

Potential Benefits of AICAR Peptide

• AMPK Activation: AICAR, short for 5-Aminoimidazole-4-carboxamide ribonucleotide, is known to stimulate AMP-activated protein kinase (AMPK) activity. AMPK is a key regulator of cellular energy homeostasis, which makes AICAR beneficial in metabolic regulation [1].
• Enhanced Endurance: Studies have shown that AICAR peptide can enhance endurance in mice by transforming fast-twitch muscle fibers into the more energy-efficient, fat-burning, slow-twitch type [2].
• Cardioprotection: AICAR has demonstrated cardioprotective properties. It has been found to limit infarct size during ischemia and improve post-ischemic heart function [3].
• Neuroprotection: Research suggests that AICAR has potential neuroprotective effects. It may mitigate neuronal damage after incidents such as stroke or spinal cord injury [4].
• Anti-Diabetic Effects: AICAR peptide has been shown to improve insulin sensitivity, presenting potential benefits for managing type 2 diabetes [5].
• Cancer Therapy Potential: While more research is needed, studies suggest AICAR might have potential in cancer therapy due its ability to inhibit cell proliferation and induce apoptosis in certain cancer cell lines [6].
• Inflammation Modulation: AICAR has been observed to exert anti-inflammatory effects, which may have significant implications in the treatment of chronic inflammatory diseases [7].

References

1. https://www.researchgate.net/ publication/6128312
2. Narkar VA, Downes M, Yu RT, et al. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008;134(3):405-415. doi:10.1016/j.cell.2008.06.051
3. Yin T, Sandhu G, Wolfgang CD, et al. Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney. J Biol Chem. 1997;272(32):19943-19950. doi:10.1074/jbc.272.32.19943
4. https://pubmed.ncbi.nlm.nih.gov/22198598/
5. https://pubmed.ncbi.nlm.nih.gov/12351423/
6. https://pubmed.ncbi.nlm.nih.gov/17638885/
7. https://pubmed.ncbi.nlm.nih.gov/19050283/

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://america.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.